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1.
J ISAKOS ; 2024 Apr 20.
Artigo em Inglês | MEDLINE | ID: mdl-38649114

RESUMO

OBJECTIVES: To analyze the bibliometric characteristics of the top 50 cited articles in elbow arthroscopy. METHODS: The Web of Science Core Collection was employed to systematically retrieve publications related to elbow arthroscopy. Subsequently, the top 50 cited articles meeting the predefined inclusion criteria were meticulously documented and subjected to comprehensive bibliometric analysis. RESULTS: The top 50 cited articles spanned the years 1999 to 2017, with the 2010s emerging as the most prolific decade. Citations per article varied from 24 to 211, and citation density ranged from 1.61 to 9.17. The United States dominated in article production and citations. Predominantly, the articles took the form of case series and expert opinions, with a notable absence of level I or II evidence. The keywords with the highest frequencies were "arthrofibrosis," "complications," and "release." These keywords formed five main clusters: stiff elbow, osteoarthritis, osteochondritis dissecans, and lateral epicondylitis. CONCLUSIONS: The majority of the top 50 cited articles in elbow arthroscopy comprised case series exhibiting Level IV or V evidence. Despite a dynamic development post-2010, elbow arthroscopy articles showed lower mean citations and citation density compared to other joints, potentially influenced by concerns about complications. However, with the increasing prevalence of elbow arthroscopy procedures, it is anticipated that higher-level articles, particularly those focusing on complications and exploring additional indications, will supersede some of the articles included in this analysis. LEVEL OF EVIDENCE: IV.

2.
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi ; 38(3): 368-372, 2024 Mar 15.
Artigo em Chinês | MEDLINE | ID: mdl-38500433

RESUMO

Objective: To summarize the current research progress on the concept, clinical presentation, diagnosis, biomechanical changes, and pathological mechanisms of the medial meniscus posterior root tear (MMPRT), and its clinical correlations with tibial rotation. Methods: The research literature on MMPRT and its relationship with tibial rotation at home and abroad in recent years was extensively consulted and summarized. Results: MMPRT is a specific and common type of medial meniscus injury of the knee joint. The occurrence of posterior medial pumping pain events following low-energy trauma in patients provides important clues for the diagnosis of this injury, with MRI being the preferred imaging modality. The biomechanical effects generated by MMPRT are similar to those caused by total removal of the medial meniscus. And this injury is usually associated with tibial rotation. MMPRT induces pathological external rotation of the tibia, which can be restored by timely medial meniscus posterior root repair. Furthermore, changes in tibial rotation are related to the healing status after medial meniscus posterior root repair. Conclusion: MMPRT is closely related to tibial rotation. Understanding the biomechanics, pathological mechanisms, and clinical correlations between the two is of great significance for improving the diagnosis and treatment strategies.


Assuntos
Meniscos Tibiais , Lesões do Menisco Tibial , Humanos , Meniscos Tibiais/cirurgia , Lesões do Menisco Tibial/cirurgia , Articulação do Joelho/cirurgia , Tíbia/cirurgia , Ruptura/cirurgia , Imageamento por Ressonância Magnética , Estudos Retrospectivos
3.
Orthop Surg ; 16(4): 894-901, 2024 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-38444379

RESUMO

OBJECTIVE: Many studies reported that tranexamic acid (TXA) was effective in reducing surgical blood loss in the perioperative period of medial open wedge high tibial osteotomy (MOWHTO). However, few studies focused on the simple topical use of TXA in MOWHTO, and the modality and dosage of topical use of TXA varied. The purpose of this study was to observe the effect of topical use of low-dose TXA on drainage volume after MOWHTO, and to analyze the related influencing factors. METHODS: Data of patients who underwent MOWHTO combined with arthroscopic knee surgery in our department from January 2019 to September 2021 were retrospectively analyzed. A total of 105 patients (38 males and 67 females, aged 57.7 ± 7.5 years) were included in this study who received topical TXA or no TXA. The patients were divided into three groups: control group (39 cases), 0.5 g TXA group (40 cases), 1 g TXA group (26 cases). Postoperative drainage volume, wound healing, incidence of hematoma and deep venous thrombosis (DVT) were observed and analyzed in the three groups. The effects of gender, hypertension and diabetes on postoperative drainage volume were analyzed using a t-test. The correlation between age, body mass index (BMI), osteotomy gap and postoperative drainage volume were analyzed using the Pearson correlation coefficient. RESULTS: The average postoperative drainage volume of the control group was 259.54 ± 226.33 mL, that of the 0.5 g TXA group was 277.18 ± 177.68 mL, and that of the 1 g TXA group was 229.15 ± 219.93 mL. There was no statistically significant difference in postoperative drainage volume among the three groups (F = 0.423, p = 0.656). There was no local hematoma and wound infection in the three groups. The wound fat liquefaction was found in one patient of the control group. The incidence of DVT was 38.9% (7/18) and 57.1% (8/14) in the control group and 0.5 TXA group, respectively. There was no significant difference in the incidence of DVT between the above two groups (p = 0.476). The average postoperative drainage volume of male patients in the three groups was higher than that of female patients, and the differences were statistically significant (p < 0.05). There was no correlation between age, BMI, osteotomy gap and postoperative drainage volume in the three groups (p > 0.05). CONCLUSION: Topical use of low-dose TXA has no significant effect on drainage volume after MOWHTO. The drainage volume after MOWHTO in male patients was more than that in female patients. Topical administration of low-dose TXA does not increase postoperative complications, such as DVT and hematoma.


Assuntos
Antifibrinolíticos , Ácido Tranexâmico , Humanos , Masculino , Feminino , Estudos de Casos e Controles , Estudos Retrospectivos , Transfusão de Sangue , Perda Sanguínea Cirúrgica , Hemorragia Pós-Operatória/prevenção & controle , Hemorragia Pós-Operatória/tratamento farmacológico , Administração Tópica , Osteotomia/efeitos adversos , Drenagem , Hematoma/induzido quimicamente , Hematoma/complicações
4.
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi ; 37(11): 1335-1341, 2023 Nov 15.
Artigo em Chinês | MEDLINE | ID: mdl-37987041

RESUMO

Objective: To summarize the clinical features, surgical methods, and prognosis of bucket-handle meniscal tears (BHMTs), and provide guidance for clinical treatment. Methods: The clinical data of 91 BHMTs patients (91 knees), who met the selection criteria and were admitted between January 2015 and January 2021, was retrospectively analyzed. There were 68 males and 23 females. Age ranged from 16 to 58 years with an average of 34.4 years. The injury was caused by sports in 68 cases, traffic accident in 15 cases, and falls or sprains in 8 cases. There were 49 cases of left knee injury and 42 cases of right knee injury. The time from the onset of symptoms to the admission ranged from 1 day to 13 months (median, 18 days), including >1 month in 35 cases and ≤1 month in 56 cases. Medial BHMTs occurred in 52 cases and lateral BHMTs in 39 cases. There were 36 cases with ACL rupture and 12 cases with discoid meniscus. The knee extension was limited more than 10° in 55 cases. According to the condition of meniscus injury, the meniscus suture with Inside-out combined with All-inside techniques (54 cases) or meniscoplasty (37 cases) under arthroscopy were selected. ACL reconstruction was performed in all patients with ACL rupture with autogenous hamstring tendon. Postoperative complications were observed. International Knee Documentation Committee (IKDC) score, Lysholm score, and Tegner score were used to evaluate knee function, and clinical failure was recorded. Results: Two patients developed intermuscular venous thrombosis, which improved after oral anticoagulant therapy. No vascular injury, postoperative infection, joint stiffness, or other complications occurred in all patients. All patients were followed up 24-95 months, with a median of 64 months. A total of 12 cases (13.19%) failed the operation and were re-operated or given oral anti-inflammatory analgesics and rehabilitation therapy. At last follow-up, IKDC score and Lysholm score of 91 patients significantly increased when compared with those before operation ( P<0.05), while Tegner score significantly decreased ( P<0.05). The above indexes of patients treated with meniscus suture and meniscoplasty were also significantly different from those before operation ( P<0.05). Conclusion: BHMTs occurs mostly in young men and is one of the important reasons for the limitation of knee extension after trauma. Arthroscopic meniscus suture and meniscoplasty can obtain good effectiveness according to individual conditions of patients. But the latter can better preserve the shape and function of meniscus, and theoretically can obtain better long-term outcomes, which needs to be confirmed by further research with larger sample size.


Assuntos
Lesões do Ligamento Cruzado Anterior , Traumatismos do Joelho , Menisco , Lesões do Menisco Tibial , Masculino , Feminino , Humanos , Adolescente , Adulto Jovem , Adulto , Pessoa de Meia-Idade , Resultado do Tratamento , Estudos Retrospectivos , Articulação do Joelho/cirurgia , Meniscos Tibiais/cirurgia , Traumatismos do Joelho/cirurgia , Traumatismos do Joelho/diagnóstico , Ruptura , Lesões do Menisco Tibial/cirurgia , Artroscopia/métodos , Lesões do Ligamento Cruzado Anterior/cirurgia
5.
Research (Wash D C) ; 6: 0189, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-37727321

RESUMO

Offensive language detection has received important attention and plays a crucial role in promoting healthy communication on social platforms, as well as promoting the safe deployment of large language models. Training data is the basis for developing detectors; however, the available offense-related dataset in Chinese is severely limited in terms of data scale and coverage when compared to English resources. This significantly affects the accuracy of Chinese offensive language detectors in practical applications, especially when dealing with hard cases or out-of-domain samples. To alleviate the limitations posed by available datasets, we introduce AugCOLD (Augmented Chinese Offensive Language Dataset), a large-scale unsupervised dataset containing 1 million samples gathered by data crawling and model generation. Furthermore, we employ a multiteacher distillation framework to enhance detection performance with unsupervised data. That is, we build multiple teachers with publicly accessible datasets and use them to assign soft labels to AugCOLD. The soft labels serve as a bridge for knowledge to be distilled from both AugCOLD and multiteacher to the student network, i.e., the final offensive detector. We conduct experiments on multiple public test sets and our well-designed hard tests, demonstrating that our proposal can effectively improve the generalization and robustness of the offensive language detector.

6.
IEEE Trans Cybern ; 53(8): 5024-5036, 2023 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-37040251

RESUMO

The existing clustering validity indexes (CVIs) show some difficulties to produce the correct cluster number when some cluster centers are close to each other, and the separation processing mechanism appears simple. The results are imperfect in case of noisy data sets. For this reason, in this study, we come up with a novel CVI for fuzzy clustering, referred to as the triple center relation (TCR) index. The originality of this index is twofold. On the one hand, a new fuzzy cardinality is built on the strength of the maximum membership degree, and a novel compactness formula is constructed by combining it with the within-class weighted squared error sum. On the other hand, starting from the minimum distance between different cluster centers, the mean distance as well as the sample variance of cluster centers in the statistical sense are further integrated. These three factors are combined by means of product to form a triple characterization of the relationship between cluster centers, and hence a 3-D expression pattern of separability is formed. Subsequently, the TCR index is put forward by combining the compactness formula with the separability expression pattern. By virtue of the degenerate structure of hard clustering, we show an important property of the TCR index. Finally, based on the fuzzy C -means (FCMs) clustering algorithm, experimental studies were conducted on 36 data sets (incorporating artificial and UCI data sets, images, the Olivetti face database). For comparative purposes, 10 CVIs were also considered. It has been found that the proposed TCR index performs best in finding the correct cluster number, and has excellent stability.

7.
J Orthop Surg (Hong Kong) ; 31(1): 10225536231165357, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-36946572

RESUMO

BACKGROUND: To investigate the effect of arthroscopy combined with high tibial osteotomy (HTO) on cartilage regeneration in patients with knee osteoarthritis. METHODS: A retrospective analysis of 50 patients with varus and medial compartment osteoarthritis of the knee treated by arthroscopy combined with HTO. One year after the operation, a second-look arthroscopy was performed to observe the cartilage regeneration. The regeneration of cartilage was evaluated by different pathological staining of some of the new cartilage. Finally, part of the new cartilages (n = 6) were taken for quantitative real-time PCR and western blotting experiments to display the mechanism of cartilage regeneration. RESULTS: One year after arthroscopy combined with HTO, the results of arthroscopy revealed the formation of new tissue in the defect area of the medial compartment's cartilage in the knee joint. In addition, different pathological staining results indicated that the new tissue was cartilage-like tissue. Furthermore, HTO potently up-regulated the expression of p-ERK1/2 at the protein level in knee osteoarthritis patients compared with control group. However, there was no significant difference in the relative expression of collagen II at mRNA and protein level between control group and knee osteoarthritis patients. CONCLUSION: Arthroscopy combined with HTO can promote cartilage regeneration in patients with knee osteoarthritis.


Assuntos
Cartilagem Articular , Osteoartrite do Joelho , Humanos , Osteoartrite do Joelho/cirurgia , Estudos Retrospectivos , Cartilagem Articular/cirurgia , Artroscopia/métodos , Regeneração , Tíbia/cirurgia , Articulação do Joelho/cirurgia , Osteotomia/métodos , Resultado do Tratamento
8.
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi ; 36(4): 495-499, 2022 Apr 15.
Artigo em Chinês | MEDLINE | ID: mdl-35426291

RESUMO

Objective: To summarize the current management of anterior cruciate ligament (ACL) injury in children and adolescents, in order to provide reference for the management of ACL injury in children and adolescents. Methods: The relevant literature at home and abroad in recent years was extensively accessed to summarize the management status of ACL injury in children and adolescent. Results: The number of ACL injury in children and adolescents is increasing every year. The diagnosis of ACL mainly depends on symptoms and signs. Rehabilitation, physeal-sparing techniques, partial transphyseal techniques, all-epiphyseal techniques, and transphyseal techniques are used to treat ACL injury in children and adolescents. Conclusion: Dynamic monitoring of knee joint in children and adolescents should be strengthened. The best treatment for ACL injury in children and adolescents is selected according to the patients' actual age, bone age, Tanner stage, and physiological conditions such as menstruation, body growth speed, and other characteristics.


Assuntos
Lesões do Ligamento Cruzado Anterior , Reconstrução do Ligamento Cruzado Anterior , Adolescente , Ligamento Cruzado Anterior/cirurgia , Lesões do Ligamento Cruzado Anterior/cirurgia , Reconstrução do Ligamento Cruzado Anterior/métodos , Criança , Epífises/cirurgia , Feminino , Humanos , Articulação do Joelho/cirurgia
9.
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi ; 36(1): 33-40, 2022 Jan 15.
Artigo em Chinês | MEDLINE | ID: mdl-35038797

RESUMO

OBJECTIVE: To explore the effectiveness of one-stage posterior medial corner (PMC) repair or reconstruction combined with anterior cruciate ligament (ACL) and posterior cruciate ligament (PCL) reconstruction in treating KD-ⅢM dislocation. METHODS: The clinical data of 15 patients with knee KD-ⅢM dislocation who met the selection criteria between January 2016 and July 2019 were retrospectively analyzed. There were 9 males and 6 females, aged 22-61 years (mean, 40.3 years). Injuries were caused by violence of flexion, valgus, and external rotation, including 10 cases of traffic accident injuries, 3 cases of crush injuries, 1 case of winch injury, and 1 case of explosion injury. The time from injury to operation ranged from 3 days to 6 months, with an average of 18.5 days. PMC repair combined with PCL+ACL reconstruction was performed in 10 cases in acute stage (within 3 weeks after injury), including 3 cases of irreducible dislocation. PMC+PCL+ACL reconstruction was performed in 5 cases with chronic dislocation. Before operation and at last follow-up, the knee joint function was evaluated by Lysholm score and International Knee Documentation Committee (IKDC) 2000 score. KT-3000 was used to evaluate the forward stability of the knee (calculated the difference of tibial anterior displacement of both knees), the X-ray films of the stress position of the knee joint was used to evaluate the valgus of the knee (calculated the difference of medial joint space width of both knees) and the backward stability (calculated the difference of tibial posterior displacement of both knees), and the internal and external rotation stability was evaluated by knee flexion 30° tibial external rotation and knee flexion 90° tibial internal rotation tests (calculated the difference of tibial internal rotation and the difference of tibial external rotation of both knees). RESULTS: The operation time was 120-240 minutes, with an average of 186.5 minutes. Patients were followed up 24-48 months, with an average of 27.4 months. There was no complication such as infection, deep vein thrombosis, vascular injury, or heterotopic ossification. At last follow-up, the Lysholm score, IKDC2000 score, the difference of tibial anterior displacement of both knees, the difference of medial joint space width of both knees, the difference of tibial posterior displacement of both knees, the difference of tibial internal rotation and the difference of tibial external rotation of both knees significantly improved when compared with preoperative ones ( P<0.05). According to the IKDC2000 valgus stability grading standard, there were 3 cases of grade C and 12 cases of grade D before operation, and 10 cases of grade A and 5 cases of grade B at last follow-up, which was significantly improved when compared with that before operation ( Z=-4.930, P=0.000). At last follow-up, the pivot shift tests of 15 patients were negative. The anterior and posterior drawer tests of 10 patients were negative, 5 patients had mild instability, both the anterior and posterior drawer tests were positive. CONCLUSION: KD-ⅢM dislocation of the knee joint can lead to the posterior medial and anterior instability. Acute dislocation combined with "dimple sign" requires surgical reduction as soon as possible to repair PMC and reconstruct PCL and ACL. In chronic patients, PMC is difficult to repair, it is recommended to reconstruct PMC, PCL, and ACL at one stage to improve knee joint stability. The early and middle effectiveness are satisfactory.


Assuntos
Lesões do Ligamento Cruzado Anterior , Reconstrução do Ligamento Cruzado Anterior , Instabilidade Articular , Lesões do Ligamento Cruzado Anterior/cirurgia , Artroscopia , Feminino , Humanos , Instabilidade Articular/diagnóstico , Instabilidade Articular/cirurgia , Articulação do Joelho/diagnóstico por imagem , Articulação do Joelho/cirurgia , Masculino , Estudos Retrospectivos , Resultado do Tratamento
11.
Research (Wash D C) ; 2021: 3067943, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-33623915

RESUMO

Emotion recognition has been used widely in various applications such as mental health monitoring and emotional management. Usually, emotion recognition is regarded as a text classification task. Emotion recognition is a more complex problem, and the relations of emotions expressed in a text are nonnegligible. In this paper, a hierarchical model with label embedding is proposed for contextual emotion recognition. Especially, a hierarchical model is utilized to learn the emotional representation of a given sentence based on its contextual information. To give emotion correlation-based recognition, a label embedding matrix is trained by joint learning, which contributes to the final prediction. Comparison experiments are conducted on Chinese emotional corpus RenCECps, and the experimental results indicate that our approach has a satisfying performance in textual emotion recognition task.

13.
Research (Wash D C) ; 2020: 2616410, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-33015633

RESUMO

The dialogue system has always been one of the important topics in the domain of artificial intelligence. So far, most of the mature dialogue systems are task-oriented based, while non-task-oriented dialogue systems still have a lot of room for improvement. We propose a data-driven non-task-oriented dialogue generator "CERG" based on neural networks. This model has the emotion recognition capability and can generate corresponding responses. The data set we adopt comes from the NTCIR-14 STC-3 CECG subtask, which contains more than 1.7 million Chinese Weibo post-response pairs and 6 emotion categories. We try to concatenate the post and the response with the emotion, then mask the response part of the input text character by character to emulate the encoder-decoder framework. We use the improved transformer blocks as the core to build the model and add regularization methods to alleviate the problems of overcorrection and exposure bias. We introduce the retrieval method to the inference process to improve the semantic relevance of generated responses. The results of the manual evaluation show that our proposed model can make different responses to different emotions to improve the human-computer interaction experience. This model can be applied to lots of domains, such as automatic reply robots of social application.

15.
IEEE Access ; 7: 3448-3458, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31328077

RESUMO

In this work we presented a new parameter-free thresholding method for image segmentation. In separating an image into two classes, the method employs an objective function that not only maximizes the between-class variance but also the distance between the mean of each class and the global mean of the image. The design of the objective function aims to circumvent the challenge that many existing techniques encounter when the underlying two classes have very different sizes or variances. Advantages of the new method are two-fold. First, it is parameter-free, meaning that it can generate consistent results. Second, the new method has a simple form that makes it easy to adapt to different applications. We tested and compared the new method with the standard Otsu method, the maximum entropy method, and the 2D Otsu method on simulated and real biomedical and photographic images and found the new method can achieve a more accurate and robust performance.

16.
Comput Intell Neurosci ; 2019: 8904389, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31191634

RESUMO

The goal of this paper is to suggest a system for intelligent learning environments with robots modeling of emotion regulation and cognition based on quantitative motivation. A detailed interactive situation for teaching words is proposed. In this study, we introduce one bottom-up collaboration method for emotion-cognition interplay and behaviour decision-making. Integration with gross emotion regulation theory lets the proposed system adapt to natural interactions between students and the robot in emotional interaction. Four key ideas are advocated, and they jointly set up a reinforcement emotion-cognition system (RECS). First, the quantitative motivation is grounded on external interactive sensory detection, which is affected by memory and preference. Second, the emotion generation triggered by an initial motivation such as external stimulus is also influenced by the state in the previous time. Third, the competitive and cooperative relationship between emotion and motivation intervenes to make the decision of emotional expression and teaching actions. Finally, cognitive reappraisal, the emotion regulation strategy, is introduced for the establishment of emotion transition combined with personalized cognition. We display that this RECS increases the robot emotional interactive performance and makes corresponding teaching decision through behavioural and statistical analysis.


Assuntos
Cognição/fisiologia , Tomada de Decisões/fisiologia , Emoções/fisiologia , Memória/fisiologia , Encéfalo/fisiologia , Humanos , Motivação/fisiologia , Rede Nervosa/fisiologia
17.
PLoS One ; 14(5): e0215216, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31048831

RESUMO

In this paper, we propose an Emotional Trigger System to impart an automatic emotion expression ability within the humanoid robot REN-XIN, in which the Emotional Trigger is an emotion classification model trained from our proposed Word Mover's Distance(WMD) based algorithm. Due to the long time delay of the WMD-based Emotional Trigger System, we propose an enhanced Emotional Trigger System to enable a smooth interaction with the robot in which the Emotional Trigger is replaced by a conventional convolution neural network and a long short term memory network (CNN_LSTM)-based deep neural network. In our experiments, the CNN_LSTM based model only need 10 milliseconds or less to finish the classification without a decrease in accuracy, while the WMD-based model needed approximately 6-8 seconds to give a result. In this paper, the experiments are conducted based on the same sub-data sets of the Chinese emotional corpus(Ren_CECps) used in former WMD experiments: one comprises 50% data for training and 50% for testing(1v1 experiment), and the other comprises 80% data for training and 20% for testing(4v1 experiment). The experiments are conducted using WMD, CNN_LSTM, CNN and LSTM. The results show that CNN_LSTM obtains the best F1 score (0.35) in the 1v1 experiment and almost the same accuracy of F1 scores (0.366 vs 0.367) achieved by WMD in the 4v1 experiment. Finally, we present demonstration videos with the same scenario to show the performance of robot control driven by CNN_LSTM-based Emotional Trigger System and WMD-based Emotional Trigger System. To improve the comparison, total manual-control performance is also recorded.


Assuntos
Emoções/classificação , Redes Neurais de Computação , Algoritmos , Humanos , Memória de Longo Prazo , Memória de Curto Prazo , Robótica
18.
PLoS One ; 13(4): e0194136, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-29624573

RESUMO

In this paper, we propose an emotion separated method(SeTF·IDF) to assign the emotion labels of sentences with different values, which has a better visual effect compared with the values represented by TF·IDF in the visualization of a multi-label Chinese emotional corpus Ren_CECps. Inspired by the enormous improvement of the visualization map propelled by the changed distances among the sentences, we being the first group utilizes the Word Mover's Distance(WMD) algorithm as a way of feature representation in Chinese text emotion classification. Our experiments show that both in 80% for training, 20% for testing and 50% for training, 50% for testing experiments of Ren_CECps, WMD features get the best f1 scores and have a greater increase compared with the same dimension feature vectors obtained by dimension reduction TF·IDF method. Compared experiments in English corpus also show the efficiency of WMD features in the cross-language field.


Assuntos
Inteligência Artificial , Simulação por Computador , Emoções , Modelos Teóricos , Algoritmos , Humanos
19.
Photochem Photobiol ; 94(1): 179-185, 2018 01.
Artigo em Inglês | MEDLINE | ID: mdl-28763104

RESUMO

Tiny but highly efficient, a light-emitting diode (LED) can power a therapy device, such as a phototherapy device, and, at the same time, decrease the device's size requirements. In this study, a LED phototherapy device was designed to investigate the possible impact on wound healing using a mouse model and a cell line exposed to red and blue light. To enhance wound phototherapy, a gelatin sponge was fabricated. Results showed that the red and blue lights promoted cell growth and wound healing, while the blue light with a gelatin sponge protected the wound from infection in the early stages of wound healing. The LED phototherapy device combined with the gelatin sponge, therefore, has potential significance in clinical application for wound healing.


Assuntos
Esponja de Gelatina Absorvível/administração & dosagem , Fototerapia/instrumentação , Cicatrização/efeitos da radiação , Ferimentos e Lesões/terapia , Animais , Linhagem Celular , Proliferação de Células/efeitos dos fármacos , Proliferação de Células/efeitos da radiação , Modelos Animais de Doenças , Fibroblastos/efeitos dos fármacos , Fibroblastos/efeitos da radiação , Humanos , Luz , Masculino , Camundongos , Camundongos Endogâmicos BALB C , Pele/citologia
20.
PLoS One ; 11(12): e0167727, 2016.
Artigo em Inglês | MEDLINE | ID: mdl-27942011

RESUMO

Low molecular weight heparins are complex polycomponent drugs that have recently become amenable to top-down analysis using liquid chromatography-mass spectrometry. Even using open source deconvolution software, DeconTools, and automatic structural assignment software, GlycReSoft, the comparison of two or more low molecular weight heparins is extremely time-consuming, taking about a week for an expert analyst and provides no guarantee of accuracy. Efficient data processing tools are required to improve analysis. This study uses the programming language of Microsoft Excel™ Visual Basic for Applications to extend its standard functionality for macro functions and specific mathematical modules for mass spectrometric data processing. The program developed enables the comparison of top-down analytical glycomics data on two or more low molecular weight heparins. The current study describes a new program, GlycCompSoft, which has a low error rate with good time efficiency in the automatic processing of large data sets. The experimental results based on three lots of Lovenox®, Clexane® and three generic enoxaparin samples show that the run time of GlycCompSoft decreases from 11 to 2 seconds when the data processed decreases from 18000 to 1500 rows.


Assuntos
Cromatografia Gasosa-Espectrometria de Massas/métodos , Heparina/química , Software
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